The History of Genetics
In the 19th century, Miescher discovered nucleic acids. In the 1940s, it was demonstrated that nucleic acids, and not proteins, as had previously been believed, are the carriers of genetic information (Avery). A decade later, Watson and Crick elucidated the structure of deoxyribonucleic acid (DNA). This was followed by the first attempts to clone and manipulate genes. In 2001, when I began my medical studies, the Human Genome Project was underway. The goal of the project was to sequence the entire human genome. While government agencies used a relatively slow method to do so, Venter was able to make much faster progress using the shotgun sequencing technique. Subsequently, sequencing techniques have improved dramatically, and with CRISPR/Cas9 (Doudna and Charpentier), it has now become somewhat easier and more cost-effective to modify genetic material. In 2000, a year before I graduated from high school, I read Ridley's book "Genome: The Autobiography of a Species". Readi...